The collection is arranged mostly chronologically. All enclosures are kept with associated letters, except in the case of photographic materials. Photographs have been separated out and follow the correspondence series.

The collection includes 232 letters, primarily from Georgia O'Keeffe (1887-1986) to her husband Alfred Stieglitz (1864-1946), dating from 1933 to 1944. Between 1915 and 1946 O'Keeffe and Stieglitz exchanged over 5,000 letters; this is only a small sample of the rich correspondence between the two. The letters are personal in nature and discuss the lives and careers of O'Keeffe and Stieglitz. Some of the letters are "notes" left by O'Keeffe to be found by Stieglitz while she was in New Mexico. On these notes Stieglitz inscribes where and when he found them; for example, "Found in my slippers / Apr 28/43 / Georgia had left for New Mexico." A few of the letters include enclosures such as feathers, tissue paper, dried flowers, or pine needles. In a letter from 1944, O'Keeffe encloses two photographs of her Black Place paintings and one photograph of a pelvis bone painting. Also included are three letters from Maria Chabot, one from "Ann", and one from Ansel Adams to Stieglitz.

The bulk of the correspondence between O'Keeffe and Stieglitz is located in the Alfred Stieglitz / Georgia O'Keeffe Archive, Yale Collection of American Literature at the Beinecke Rare Book and Manuscript Library. Selections from the O'Keeffe/Stieglitz correspondence have been published in the following: Greenough, Sarah, ed. My Faraway One: Selected Letters of Georgia O'Keeffe and Alfred Stieglitz. Vol. 1 (1915-1933). New Haven: Yale University Press, 2011.