This collection is arranged into five series: Series I: Correspondence, Series II: Photographic Material, Series III: Ephemera, Series IV: Legal Documents, Series V: Clippings.

The bulk of the collection consists of handwritten letters from Georgia O'Keeffe to her sister, Anita O'Keeffe Young, dating from the 1940s to the 1970s. The letters largely relate to personal matters, daily activities, and the management of O'Keeffe's paintings. There is some correspondence between O'Keeffe and Robert R. Young, Anita O'Keeffe Young's husband, and his assistant Florence McCormick, related to financial matters. Additionally, there are five small photographs and one article clipping. Accruals for this collection include additional correspondence, primarily of a business nature relating to Georgia O'Keeffe paintings in the possession of Anita Young and her estate. Also included are over 40 family photographs, over 100 photographs of O'Keeffe paintings, and some images of Ireland, as well as ephemera related to Isabel Dunham Wyckoff Totto (Georgia O'Keeffe's grandmother) and legal documents concerning O'Keeffe's lawsuit with Doris Bry and the settlement of O'Keeffe's estate.

Anita O'Keeffe Young (1891-1985), a younger sister of Georgia O'Keeffe, was a noted hostess and philanthropist. Young was married to Robert Ralph Young (1897-1958), a United States financier, industrialist, and railroad magnate. They had one daughter, Eleanor "Cookie" Young, who was known as a "Glamour Debutante". She was killed in a 1941 plane crash. Young purchased several paintings by O'Keeffe and kept them in her three residences: Montsorrel in Palm Beach, Florida; Fairholme in Newport, Rhode Island; and, a New York City apartment. David W. Wallace (1924-2017), corporate attorney and philanthropist, was a friend and personal attorney of Anita O'Keeffe Young. At the request of Georgia O'Keeffe and Anita Young, he often consulted with Doris Bry over the planned disposition of Young's art collection, particularly the loaned and owned O'Keeffe paintings. David Wallace served in the 1st Infantry Division during World War II, received his bachelor's degree in Engineering from Yale, and later graduated from Harvard Law School. He was married to Jean McLean Wallace.